8-O-BENZOYL-HYDROXY-QUINOLINE-7-CARBALDEHYDE

Base Information

• Chemical Name: 8-O-BENZOYL-HYDROXY-QUINOLINE-7-CARBALDEHYDE
• CAS No.: 936497-79-9
• Molecular Formula: C₁₇H₁₁NO₃
• Molecular Weight: 277.279
• Mol file: 936497-79-9.mol

Synonyms:Benzoic acid 7-formyl-quinolin-8-yl ester

Chemical Property of 8-O-BENZOYL-HYDROXY-QUINOLINE-7-CARBALDEHYDE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

7-Formylquinolin-8-ylbenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-O-BENZOYL-HYDROXY-QUINOLINE-7-CARBALDEHYDE

There total 3 articles about 8-O-BENZOYL-HYDROXY-QUINOLINE-7-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzoic acid ((E)-7-propenyl)-quinolin-8-yl ester → Benzoic acid 7-formyl-quinolin-8-yl ester (936497-79-9)

Guidance literature:

With dimethylsulfide; ozone; Multistep reaction; 1.) MeOH, CH₂Cl₂, -78 deg C, 30 min, 2.) MeOH, CH₂Cl₂, 25 deg C, 16 h;

DOI:10.1021/ja974181p

Reference yield:

7-(1-propenyl)-8-quinolinol (67818-50-2) → Benzoic acid 7-formyl-quinolin-8-yl ester (936497-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / pyridine / 16 h / 50 °C

2: 1.) O₃, 2.) Me₂S / 1.) MeOH, CH₂Cl₂, -78 deg C, 30 min, 2.) MeOH, CH₂Cl₂, 25 deg C, 16 h

With pyridine; dimethylsulfide; ozone;

DOI:10.1021/ja974181p

Reference yield:

benzoyl chloride (98-88-4) → Benzoic acid 7-formyl-quinolin-8-yl ester (936497-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / pyridine / 16 h / 50 °C

2: 1.) O₃, 2.) Me₂S / 1.) MeOH, CH₂Cl₂, -78 deg C, 30 min, 2.) MeOH, CH₂Cl₂, 25 deg C, 16 h

With pyridine; dimethylsulfide; ozone;

DOI:10.1021/ja974181p

upstream raw materials:

7-(1-propenyl)-8-quinolinol

benzoyl chloride

Downstream raw materials:

8-hydroxy-7-quinolinecarboxaldehyde

Refernces