N₁-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide

Base Information

• Chemical Name: N₁-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide
• CAS No.: 1400937-14-5
• Molecular Formula: C₁₆H₁₅N₃O₂
• Molecular Weight: 281.314

Synonyms:N₁-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide

Chemical Property of N₁-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide

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Technology Process of N₁-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide

There total 1 articles about N₁-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-amino-3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]isoxazole (881398-62-5) + ethyl 2-cyanoacetate (105-56-6) → N1-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide (1400937-14-5)

Guidance literature:

In ethanol; for 5h; Reflux;

DOI:10.1016/j.ejmech.2012.07.029

Reference yield: 87.0%

N1-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide (1400937-14-5) + benzaldehyde (100-52-7) + malononitrile (109-77-3) → (E)-6-amino-1-(3-methyl-5-(4-methylstyryl)isoxazol-4-yl)-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile

Guidance literature:

With polyethylene glycol-400; at 20 ℃; for 4h;

DOI:10.1080/00397911.2020.1787449

Reference yield: 82.0%

N1-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide (1400937-14-5) + 2-nitro-benzaldehyde (552-89-6) → N1-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-(E)-2-cyano-3-(2-nitrophenyl)-2-propenamide (1400937-20-3)

Guidance literature:

With piperidine; In ethanol; for 4h; Reflux;

DOI:10.1016/j.ejmech.2012.07.029

upstream raw materials:

4-amino-3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]isoxazole

ethyl 2-cyanoacetate

Downstream raw materials:

N₁-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-(E)-2-cyano-3-(2-nitrophenyl)-2-propenamide

N₁-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-(E)-3-(5-chloro-2-nitrophenyl)-2-cyano-2-propenamide

N₃-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-amino-3-quinolinecarboxamide

2-methyl-3-{3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-3,4-dihydropyrimido[4,5-b]quinolin-4-one

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