(S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride

Base Information

Chemical Name:(S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride
CAS No.:1351168-71-2
Molecular Formula:C₁₇H₂₁FN₂O₄*ClH
Molecular Weight:372.824
Hs Code.:

Synonyms:(S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride

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Chemical Property of (S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride

Chemical Property:

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Technology Process of (S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride

There total 4 articles about (S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351168-43-8
(S)-tert-butyl 4-(3-(2-fluoro-4-(methoxycarbonyl)phenoxy)-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

: 1351168-71-2
(S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; isopropyl alcohol; at 20 ℃;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1351168-71-2
(S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1,2-dichloro-ethane / 0.25 h / 20 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

4.1: hydrogenchloride / ethyl acetate; isopropyl alcohol / 20 °C

With hydrogenchloride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1351167-84-4
(R)-tert-butyl 4-(3-(methylsulfonyloxy)-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

: 1351168-71-2
(S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

2: hydrogenchloride / ethyl acetate; isopropyl alcohol / 20 °C

With hydrogenchloride; potassium carbonate; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;