(S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate

Base Information

Chemical Name:(S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate
CAS No.:1351167-50-4
Molecular Formula:C₂₃H₂₂ClF₄N₃O₄
Molecular Weight:515.892
Hs Code.:

Synonyms:(S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate

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Chemical Property of (S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate

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Technology Process of (S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate

There total 5 articles about (S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1351168-71-2
(S)-methyl 3-fluoro-4-(2-oxo-1-(piperidin-4-yl)pyrrolidin-3-yloxy)benzoate hydrochloride

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 1351167-50-4
(S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1351167-50-4
(S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 1,2-dichloro-ethane / 0.25 h / 20 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

4.1: hydrogenchloride / ethyl acetate; isopropyl alcohol / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1351167-84-4
(R)-tert-butyl 4-(3-(methylsulfonyloxy)-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

: 1351167-50-4
(S)-methyl 4-(1-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)-2-oxopyrrolidin-3-yloxy)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

2: hydrogenchloride / ethyl acetate; isopropyl alcohol / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;