3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide

Base Information

Chemical Name:3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide
CAS No.:1020204-27-6
Molecular Formula:C₂₈H₂₉ClN₄O₂
Molecular Weight:489.017
Hs Code.:

Synonyms:3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide

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Chemical Property of 3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide

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Technology Process of 3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide

There total 8 articles about 3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.5%

: 850567-23-6
3-(cyclopropylaminocarbonyl)benzeneboronic acid

: 1020206-21-6
3-chloro-5-iodo-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol

: 1020204-27-6
3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ISOPROPYLAMIDE; water; at 20 - 90 ℃; for 1.5h;

Reference yield:

: 20691-89-8
1-methyl-4-piperidinemethanol

: 1020204-27-6
3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / dimethyl sulfoxide / 20 - 40 °C / Inert atmosphere

2.1: sodium iodate; iodine / sulfuric acid / 30 °C

3.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 20 - 100 °C / Inert atmosphere

4.1: triphenyl phosphite; ammonium metavanadate; hydrogen / platinum on carbon

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate; CyJohnPhos / ISOPROPYLAMIDE / 80 - 130 °C

6.1: hydrogenchloride; sodium nitrite / water / 1.08 h / 0 - 20 °C

6.2: 0.08 h

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE; water / 1.5 h / 20 - 90 °C

With triphenyl phosphite; hydrogenchloride; ammonium metavanadate; sodium iodate; hydrogen; iodine; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium t-butanolate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; platinum on carbon; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CyJohnPhos; In 1,4-dioxane; ISOPROPYLAMIDE; sulfuric acid; water; dimethyl sulfoxide;

Reference yield:

: 902454-25-5
1-methyl-4-[(4-nitrophenoxy)methyl]piperidine

: 1020204-27-6
3-(3-chloro-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indol-5-yl)-N-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium iodate; iodine / sulfuric acid / 30 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 20 - 100 °C / Inert atmosphere

3.1: triphenyl phosphite; ammonium metavanadate; hydrogen / platinum on carbon

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate; CyJohnPhos / ISOPROPYLAMIDE / 80 - 130 °C

5.1: hydrogenchloride; sodium nitrite / water / 1.08 h / 0 - 20 °C

5.2: 0.08 h

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE; water / 1.5 h / 20 - 90 °C

With triphenyl phosphite; hydrogenchloride; ammonium metavanadate; sodium iodate; hydrogen; iodine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium t-butanolate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; platinum on carbon; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CyJohnPhos; In 1,4-dioxane; ISOPROPYLAMIDE; sulfuric acid; water;