(R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester

Base Information

Chemical Name:(R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester
CAS No.:1432502-66-3
Molecular Formula:C₂₄H₂₂ClFN₂O₄
Molecular Weight:456.901
Hs Code.:

Synonyms:(R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester

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Chemical Property of (R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester

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Technology Process of (R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester

There total 6 articles about (R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₈ClFN₂O₅

: 70-11-1
α-bromoacetophenone

: 1432502-66-3
(R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

Reference yield:

: 1382978-06-4
(R)-3-[N-(4-bromobenzyl)-N'-t-butoxycarbonylhydrazino]-2-hydroxypropionic acid methyl ester

: 1432502-66-3
(R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

3: potassium carbonate / water; ethanol / 0.25 h / 120 °C / Inert atmosphere; Microwave irradiation

4: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 3-[N-(4-bromobenzyl)hydrazino]-2-hydroxypropionic acid ethyl ester

: 1432502-66-3
(R)-3-[N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid 2-oxo-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

2: potassium carbonate / water; ethanol / 0.25 h / 120 °C / Inert atmosphere; Microwave irradiation

3: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;