(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate

Base Information

Chemical Name:(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate
CAS No.:1620408-84-5
Molecular Formula:C₃₅H₅₉NO₅
Molecular Weight:573.857
Hs Code.:

Synonyms:(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate

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Chemical Property of (S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate

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Technology Process of (S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate

There total 15 articles about (S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 2018-66-8
Z-Leu-OH

: 1620408-80-1
(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-ol

: 1620408-84-5
(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/ja505639u

Reference yield:

: 1620408-79-8
(S)-henicos-7-yn-10-ol

: 1620408-84-5
(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate

Guidance literature:: Multi-step reaction with 3 steps

1: quinoline; 5% Pd-CaCO3; hydrogen / methanol / 18 h / 20 °C / 760.05 Torr / Inert atmosphere

2: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane; decane / 23 h / 0 - 20 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C / Inert atmosphere

With quinoline; tert.-butylhydroperoxide; dmap; bis(acetylacetonate)oxovanadium; 5% Pd-CaCO3; hydrogen; dicyclohexyl-carbodiimide; In methanol; decane; dichloromethane;
DOI:10.1021/ja505639u

Reference yield:

: 1620408-99-2
(S,Z)-henicos-7-en-10-ol

: 1620408-84-5
(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate

Guidance literature:: Multi-step reaction with 2 steps

1: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane; decane / 23 h / 0 - 20 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C / Inert atmosphere

With tert.-butylhydroperoxide; dmap; bis(acetylacetonate)oxovanadium; dicyclohexyl-carbodiimide; In decane; dichloromethane;
DOI:10.1021/ja505639u