5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Base Information

Chemical Name:5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one
CAS No.:1023620-57-6
Molecular Formula:C₂₀H₁₉NO₃
Molecular Weight:321.376
Hs Code.:

Synonyms:5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one

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Chemical Property of 5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Chemical Property:

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Technology Process of 5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one

There total 1 articles about 5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1023620-28-1
7-(benzyloxycarbonylamino)-6,7,8,9-tetrahydro-benzocyclohepten-6-one

: 1023620-57-6
5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Guidance literature:: With pyrrolidine; In acetic acid; at 110 ℃; for 5h; Inert atmosphere;

Reference yield: 43.0%

: 3277-89-2
phenethylmagnesium bromide

: 1023620-57-6
5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one

: 1023620-59-8
5-(3-phenylpropyl)-7-(benzyloxycarbonyl-amino)-5,7,8,9-tetrahydro-benzocyclohepten-6-one

Guidance literature:: phenethylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether; at -50 ℃; Inert atmosphere;

5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one; In tetrahydrofuran; diethyl ether; water; at -40 ℃;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water;

Reference yield:

: 3277-89-2
phenethylmagnesium bromide

: 1023620-57-6
5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one

: cis-5-(3-phenylpropyl)-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Guidance literature:: phenethylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether; at -50 ℃; for 0.75h; Inert atmosphere;

5-methylene-7-(benzyloxycarbonylamino)-5,7,8,9-tetrahydrobenzocyclohepten-6-one; In tetrahydrofuran; diethyl ether; at -40 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; Inert atmosphere;
DOI:10.1016/j.bmc.2012.06.041