3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide
CAS No.:1637586-67-4
Molecular Formula:C₂₁H₂₃F₄N₅O
Molecular Weight:437.44
Hs Code.:

Synonyms:3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide

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Chemical Property of 3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of 3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide

There total 7 articles about 3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.2%

: 1637586-58-3
C₃₁H₃₉F₄N₅O₅

: 1637586-67-4
3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.3390/molecules19056163

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1637586-67-4
3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 4 h / 60 °C

2: dichloromethane / 3 h / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

4: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

5: mercury dichloride; triethylamine / dichloromethane / 0 - 20 °C

6: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; mercury dichloride; In ethanol; dichloromethane; water; acetone;
DOI:10.3390/molecules19056163

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1637586-67-4
3-fluoro-N-(1-(4-guanidinobenzyl)piperidin-4-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 4 h / 60 °C

2: dichloromethane / 3 h / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

4: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

5: mercury dichloride; triethylamine / dichloromethane / 0 - 20 °C

6: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; mercury dichloride; In ethanol; dichloromethane; water; acetone;
DOI:10.3390/molecules19056163