2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide

Base Information

Chemical Name:2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide
CAS No.:177558-34-8
Molecular Formula:C₂₇H₂₄N₂O₅S
Molecular Weight:488.564
Hs Code.:

Synonyms:2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide

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Technology Process of 2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide

There total 11 articles about 2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.3%

: 96-32-2
bromoacetic acid methyl ester

: 177559-92-1
2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

: 177558-34-8
2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 76509-17-6
3-benzyloxypyridine

: 177558-34-8
2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide

Guidance literature:: Multi-step reaction with 11 steps

1: benzene / 2 h / 65 °C

2: 1.) aq. NaOH / 1.) EtOH, 30 min, 2.) ETOH, 1 h

3: 2.) 1,8-diazabicyclo<5.4.0>undec-7-ene, 3.) KOtBu

4: NaH / dimethylformamide / 2 h / Ambient temperature

5: aq. KOH / dimethylsulfoxide / 8 h / Heating

6: toluene / 1 h / Heating

7: benzene / 48 h / Ambient temperature

8: tetrahydrofuran / 1 h / 0 °C

9: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

10: BBr₃ / CH₂Cl₂ / 1 h / 0 °C

11: K₂CO₃, KI / dimethylformamide / 5 h

With potassium hydroxide; ammonium hydroxide; sodium hydroxide; potassium tert-butylate; boron tribromide; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 177559-90-9
6-benzyloxy-2-methylthioindolizine

: 177558-34-8
2-(8-(carbomethoxymethyloxy)-2-methylthio-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / 48 h / Ambient temperature

2: tetrahydrofuran / 1 h / 0 °C

3: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

4: BBr₃ / CH₂Cl₂ / 1 h / 0 °C

5: K₂CO₃, KI / dimethylformamide / 5 h

With ammonium hydroxide; boron tribromide; potassium carbonate; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm960395q