2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

Base Information

Chemical Name:2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide
CAS No.:177559-92-1
Molecular Formula:C₂₄H₂₀N₂O₃S
Molecular Weight:416.5
Hs Code.:

Synonyms:2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

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Chemical Property of 2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

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Technology Process of 2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

There total 10 articles about 2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177559-91-0
2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

: 177559-92-1
2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm960395q

Reference yield:

: 76509-17-6
3-benzyloxypyridine

: 177559-92-1
2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: benzene / 2 h / 65 °C

2: 1.) aq. NaOH / 1.) EtOH, 30 min, 2.) ETOH, 1 h

3: 2.) 1,8-diazabicyclo<5.4.0>undec-7-ene, 3.) KOtBu

4: NaH / dimethylformamide / 2 h / Ambient temperature

5: aq. KOH / dimethylsulfoxide / 8 h / Heating

6: toluene / 1 h / Heating

7: benzene / 48 h / Ambient temperature

8: tetrahydrofuran / 1 h / 0 °C

9: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

10: BBr₃ / CH₂Cl₂ / 1 h / 0 °C

With potassium hydroxide; ammonium hydroxide; sodium hydroxide; potassium tert-butylate; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 177559-90-9
6-benzyloxy-2-methylthioindolizine

: 177559-92-1
2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 48 h / Ambient temperature

2: tetrahydrofuran / 1 h / 0 °C

3: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

4: BBr₃ / CH₂Cl₂ / 1 h / 0 °C

With ammonium hydroxide; boron tribromide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jm960395q