(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Base Information

Chemical Name:(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
CAS No.:1448458-83-0
Molecular Formula:C₂₄H₁₈O₅S
Molecular Weight:418.47
Hs Code.:

Synonyms:(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Suppliers and Price of (5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

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Technology Process of (5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

There total 6 articles about (5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 162011-90-7
rofecoxib

: 1448458-83-0
(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Guidance literature:: With piperidine; In methanol; at 20 ℃; for 12h;
DOI:10.1021/acs.analchem.1c01978

Reference yield: 89.0%

: 1448458-83-0
(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Guidance literature:: With piperidine; In methanol; at 20 ℃; for 12h; Darkness;

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 1448458-83-0
(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C

2.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C

2.2: 2.5 h / 25 - 58 °C

3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 1 h

3.3: 4 h / 60 °C

4.1: sodium carbonate / methanol / 65 °C

With sulfuric acid; hydrogen bromide; dihydrogen peroxide; sodium carbonate; acetic acid; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.04.062