3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid

Base Information

Chemical Name:3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid
CAS No.:865722-92-5
Molecular Formula:C₁₉H₁₈Br₂N₂O₇S
Molecular Weight:578.235
Hs Code.:

Synonyms:3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid

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Chemical Property of 3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid

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Technology Process of 3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid

There total 7 articles about 3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 865722-91-4
(E)-methyl 3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylate

: 865722-92-5
3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid

Guidance literature:: With potassium hydroxide; water; In methanol; at 20 ℃; for 12h;
DOI:10.1021/ol0513286

Reference yield:

: 865722-99-2
N-(3-bromopropyl)-2-nitrobenzenesulfonamide

: 865722-92-5
3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / Cs₂CO₃; NaI / acetonitrile / 6 h / 50 °C

2: 94 percent / PPh₃; DEAD / toluene / 0.33 h / 20 °C

3: 89 percent / Pd(OAc)2; Bu₄NBr; KOAc / 4 Angstroem molecular sieves / dimethylformamide / 8 h / 20 °C

4: 95 percent / KOH; H₂O / methanol / 12 h / 20 °C

With palladium diacetate; potassium hydroxide; tetrabutylammomium bromide; water; potassium acetate; caesium carbonate; triphenylphosphine; sodium iodide; diethylazodicarboxylate; 4 A molecular sieve; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile; 3: Heck reaction;
DOI:10.1021/ol0513286

Reference yield:

: 865722-89-0
N-[3-(2,6-dibromo-4-iodophenoxy)propyl]-2-nitrobenzenesulfonamide

: 865722-92-5
3-{3,5-dibromo-4-[3-(N-methyl-2-nitrophenylsulfonamido)propoxy]phenyl}acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / PPh₃; DEAD / toluene / 0.33 h / 20 °C

2: 89 percent / Pd(OAc)2; Bu₄NBr; KOAc / 4 Angstroem molecular sieves / dimethylformamide / 8 h / 20 °C

3: 95 percent / KOH; H₂O / methanol / 12 h / 20 °C

With palladium diacetate; potassium hydroxide; tetrabutylammomium bromide; water; potassium acetate; triphenylphosphine; diethylazodicarboxylate; 4 A molecular sieve; In methanol; N,N-dimethyl-formamide; toluene; 2: Heck reaction;
DOI:10.1021/ol0513286