2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid

Base Information

Chemical Name:2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid
CAS No.:458532-02-0
Molecular Formula:C₂₆H₄₀N₄O₈
Molecular Weight:536.626
Hs Code.:

2-(<i>tert</i>-butoxycarbonylamino-methyl)-<i>N</i>-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid

Synonyms:2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid

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Chemical Property of 2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid

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Technology Process of 2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid

There total 2 articles about 2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 458532-01-9
N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-(benzyloxycarbonyl)propionyl]-leucyl-O-methyl-tyrosine N-methylamide

: 458532-02-0
2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h; normal pressure;
DOI:10.1248/cpb.50.239

Reference yield:

: H-Leu-Tyr(Me)-NHMe*HCl

: 458532-02-0
2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: EDC; Et₃N; HOBt / dimethylformamide / 21 h / -3 - 0 °C

2: 91 percent / H₂ / 10 percent Pd/C / methanol / 1 h / 20 °C / normal pressure

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.50.239

Reference yield: 90.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 458532-02-0
2-(tert-butoxycarbonylamino-methyl)-N-{1-[2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butyl}-malonamic acid

: 458532-03-1
N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-(benzyloxycarbamoyl)propionyl]-leucyl-O-methyl-tyrosine N-methylamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at -3 - 0 ℃; for 21h;
DOI:10.1248/cpb.50.239