tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

Base Information

Chemical Name:tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate
CAS No.:1349770-90-6
Molecular Formula:C₃₉H₄₈FN₅O₉S
Molecular Weight:781.903
Hs Code.:

tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

Synonyms:tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

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Chemical Property of tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

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Technology Process of tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

There total 9 articles about tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245648-96-7
2-bromo-5-isopropylsulfonyl-pyridine

: 1349770-89-3
tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

: 1349770-90-6
tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 95 ℃; for 2h; Inert atmosphere;

Reference yield:

: 381233-96-1
2-amino-3-iodo-5-bromopyridine

: 1349770-90-6
tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

2.1: dmap / dichloromethane / 3 h / 20 °C

3.1: water; sodium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.25 h / 55 °C

4.2: 1.75 h / 20 - 65 °C

5.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Inert atmosphere

With dmap; N-chloro-succinimide; copper(l) iodide; water; potassium acetate; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 905966-34-9
5-bromo-3-(2-(trimethylsilyl)ethynyl)pyridine-2-amine

: 1349770-90-6
tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]isoxazol-3-yl]-3-fluoro-phenyl]methyl]-N-methyl-carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / dichloromethane / 3 h / 20 °C

2.1: water; sodium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.25 h / 55 °C

3.2: 1.75 h / 20 - 65 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Inert atmosphere

With dmap; N-chloro-succinimide; water; potassium acetate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;