2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide

Base Information

Chemical Name:2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide
CAS No.:439660-16-9
Molecular Formula:C₁₇H₂₁FN₄OS
Molecular Weight:348.444
Hs Code.:

2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3<i>H</i>-imidazol-4-yl)-ethyl]-amide

Synonyms:2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide

Suppliers and Price of 2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide

There total 7 articles about 2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 75-16-1
methylmagnesium bromide

: N-[(4-cyano-3-fluorophenyl)(1-methyl-1H-imidazol-5-yl)methylene]-2-methyl-[S(R)]-propanesulfinamide

: 439660-16-9
2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃;
DOI:10.1016/S0040-4039(01)01513-1

Reference yield:

: 452-74-4
4-bromo-3-fluorotoluene

: 439660-16-9
2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: n-BuLi; Et₃SiCl / tetrahydrofuran / 2 h / 0 °C

2: 48 percent / MnO₂ / CH₂Cl₂; acetonitrile / 3 h

3: 76 percent / Ti(OEt)4 / tetrahydrofuran / 72 h / Heating

4: tetrahydrofuran / -78 °C

With manganese(IV) oxide; titanium(IV) tetraethanolate; n-butyllithium; triethylsilyl chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(01)01513-1

Reference yield:

: 101048-76-4
4-cyano-3-fluorobenzaldehyde

: 439660-16-9
2-methyl-propane-2-sulfinic acid [1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: n-BuLi; Et₃SiCl / tetrahydrofuran / 2 h / 0 °C

2: 48 percent / MnO₂ / CH₂Cl₂; acetonitrile / 3 h

3: 76 percent / Ti(OEt)4 / tetrahydrofuran / 72 h / Heating

4: tetrahydrofuran / -78 °C

With manganese(IV) oxide; titanium(IV) tetraethanolate; n-butyllithium; triethylsilyl chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(01)01513-1