3-(2,4-dimethoxypyrimidin-5-ylmethyl)benzoic acid ethyl ester

Base Information

• Chemical Name: 3-(2,4-dimethoxypyrimidin-5-ylmethyl)benzoic acid ethyl ester
• CAS No.: 1048028-24-5
• Molecular Formula: C₁₆H₁₈N₂O₄
• Molecular Weight: 302.33
• Mol file: 1048028-24-5.mol

Synonyms:3-(2,4-dimethoxypyrimidin-5-ylmethyl)benzoic acid ethyl ester

Chemical Property of 3-(2,4-dimethoxypyrimidin-5-ylmethyl)benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-(2,4-dimethoxypyrimidin-5-ylmethyl)benzoic acid ethyl ester

There total 2 articles about 3-(2,4-dimethoxypyrimidin-5-ylmethyl)benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-bromo-2,4-dimethoxypyrimidine (56686-16-9) + (3-ethoxycarbonylbenzyl)zinc chloride * lithium chloride → 3-(2,4-dimethoxypyrimidin-5-ylmethyl)benzoic acid ethyl ester (1048028-24-5)

Guidance literature:

With bis(acetylacetonate)nickel(II); triphenylphosphine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 60 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/b803072c

Reference yield: 55.0%

5-bromo-2,4-dimethoxypyrimidine (56686-16-9) + [3-(ethoxycarbonyl)benzyl]zinc pivalate (1344727-37-2) → 3-(2,4-dimethoxypyrimidin-5-ylmethyl)benzoic acid ethyl ester (1048028-24-5)

Guidance literature:

[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride; In tetrahydrofuran; at 25 ℃; for 2h;

upstream raw materials:

5-bromo-2,4-dimethoxypyrimidine

[3-(ethoxycarbonyl)benzyl]zinc pivalate