56686-16-9

Basic information

• Product Name: 5-BROMO-2,4-DIMETHOXYPYRIMIDINE
• Synonyms: 5-BROMO-2,6-DIMETHOXYPYRIMIDINE;5-BROMO-2,4-DIMETHOXYPYRIMIDINE;Bromo-2,4-dimethoxypyrimidine;5-BROMO-2,4-DIMETHOXYPYRIMIDINE 97+%;5-BROMO-2,4-DIMETHOXPYRIMIDINE;Nsc81442;2,4-DiMethoxy-5-broMopyriMidine;5-BroMo-2,4-bis(Methyloxy)pyriMidine
• CAS NO: 56686-16-9
• Molecular Formula: C₆H₇BrN₂O₂
• Molecular Weight: 219.04
• Product Categories: Pyrimidine;Alkoxy;Organohalides;Nucleotides and Nucleosides;5-FOA;Bases & Related Reagents;Nucleotides;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Building Blocks;C6 to C8;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 56686-16-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 62-65 °C(lit.)
• Boiling Point: 125 °C / 17mmHg
• Flash Point: 133.4 °C
• Appearance: White to pale yellow/Powder or Crystalline Powder
• Density: 1.563 g/cm³
• Vapor Pressure: 0.00245mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetone, Dichloromethane
• PKA: 1.27±0.29(Predicted)
• CAS DataBase Reference: 5-BROMO-2,4-DIMETHOXYPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,4-DIMETHOXYPYRIMIDINE(56686-16-9)
• EPA Substance Registry System: 5-BROMO-2,4-DIMETHOXYPYRIMIDINE(56686-16-9)

Safety Data

• Hazard Codes: Xi,Xn
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 56686-16-9(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

InChI:InChI=1/C6H7BrN2O2/c1-10-5-4(7)3-8-6(9-5)11-2/h3H,1-2H3

Upstream product

• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 3551-55-1 2,4-dimethoxypyrimidine 
• 123551-51-9 5,5'-Mercuri-bis-(2,4-dimethoxypyrimidine) 
• 123551-48-4 5-Acetoxymercuri-2,4-dimethoxypyrimidine 

Downstream Products

• 4212-49-1 5-ethyluracil 
• 65-71-4 thymin 
• 148214-56-6 5-bromo-2-methoxypyrimidin-4-amine 
• 936250-17-8 2,4‐dimethoxy‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)pyrimidine 
• 794521-24-7 (2,4-dimethoxy-5-pyrimidinyl)-(4-ethylphenyl) methanol 
• 52606-02-7 2,4-dimethoxy-5-pyrimidine carboxaldehyde 
• 1023754-47-3 (tert-butyldimethylsilanyl)(2,4-dimethoxypyrimidin-5-yl)(3,4,5-trimethoxyphenyl)amine 
• 5151-34-8 2,4-Dimethoxy-5-methylpyrimidine 
• 60186-89-2 4-bromo-2,6-dimethoxy-pyrimidine 
• 1335213-01-8 2,4-dimethoxy-5-(4-methoxyphenyl)pyrimidine 
• 89641-18-9 2,4-dimethoxypyrimidin-5-ylboronic acid 
• 1423122-46-6 p-tolyl(4-bromo-2,6-dimethoxy-5-pyrimidineyl)methanone 
• 1423122-41-1 phenyl(4-bromo-2,6-dimethoxy-5-pyrimidineyl)methanone 
• 110821-05-1 5-(2,4-dimethoxypyrimidinyl)-1-phenylmethanol 

Relevant articles and documents

Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro

Flaviviruses, such as Dengue (DENV) and Zika (ZIKV) viruses, represent a severe health burden. There are currently no FDA-approved treatments, and vaccines against most flaviviruses are still lacking. We have developed several flexible analogues (“fleximers”) of the FDA-approved nucleoside Acyclovir that exhibit activity against various RNA viruses, demonstrating their broad-spectrum potential. The current study reports activity against DENV and Yellow Fever Virus (YFV), particularly for compound 1. Studies to elucidate the mechanism of action suggest the flex-analogue triphosphates, especially 1-TP, inhibit DENV and ZIKV methyltransferases, and a secondary, albeit weak, effect on the DENV RNA-dependent RNA polymerase was observed at high concentrations. The results of these studies are reported herein.

Metallation of 2,4-dialkoxy-5-bromopyrimidine and formylation with dimethylformamide: Isolation of 2,6-dialkoxy-5-dimethylaminopyrimidine-4- carboxaldehyde

Direct metallation of 2,4-dialkoxy-5-bromopyrimidine with lithium diisopropylamide and consequent trapping by dimethylformamide resulted unexpectedly in the formation of 2,6-dialkoxy-5-dimethylaminopyrimidine-4- carboxaldehyde via displacement of bromine by dimethylamine moiety of dimethylformamide. Copyright

AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS

The present invention relates to novel compounds of formula (I)' or a salt thereof: wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11 -membered heteroaryl bicyclic group; A is a group P