Aminoethylphosphinic acid

Base Information

• Chemical Name: Aminoethylphosphinic acid
• CAS No.: 74333-44-1
• Molecular Formula: C2H8NO2P
• Molecular Weight: 109.065
• European Community (EC) Number: 426-930-0
• UNII: G4888SY0QO
• DSSTox Substance ID: DTXSID50995871
• Wikidata: Q27278734
• ChEMBL ID: CHEMBL37702
• Mol file: 74333-44-1.mol

Synonyms:1-aminoethylphosphinate;1-aminoethylphosphinic acid;1-aminoethylphosphinic acid, (+)-isomer;1-aminoethylphosphinic acid, (+-)-isomer;1-aminoethylphosphinic acid, sodium salt, (+-)-isomer

Chemical Property of Aminoethylphosphinic acid

Chemical Property:

• Boiling Point: 268.2 °C at 760 mmHg
• Flash Point: 116 °C
• PSA: 86.79000
• LogP: 0.45840
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 108.02144046
• Heavy Atom Count: 6
• Complexity: 64.6

Purity/Quality:

≥98%, ^*data from raw suppliers

Aminoethylphosphinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(N)[P+](=O)O

Technology Process of Aminoethylphosphinic acid

There total 8 articles about Aminoethylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(benzhydrylamino)ethylphosphinic acid (65577-30-2) → (1-aminoethyl)phosphinic acid (74333-44-1)

Guidance literature:

With hydrogenchloride; at 100 ℃;

Reference yield: 55.0%

Acetaldehyde oxime (107-29-9) → (1-aminoethyl)phosphinic acid (74333-44-1)

Guidance literature:

With hydrogenchloride; hypophosphorous acid; In methanol; at 20 ℃; for 17h; Reflux; Inert atmosphere;

DOI:10.1016/j.mencom.2011.03.017

Reference yield: 42.0%

bis(trimethylsilyl)phosphonite (30148-50-6) + Eth-(E)-ylidene-trityl-amine (120060-76-6) → C4H13N2O2P + (1-aminoethyl)phosphinic acid (74333-44-1)

Guidance literature:

bis(trimethylsilyl)phosphonite; Eth-(E)-ylidene-trityl-amine; In dichloromethane; at 25 ℃; for 12h;

With hydrogenchloride; In methanol; for 0.25h; Further stages.; Heating;

DOI:10.1021/jo070266p

upstream raw materials:

1-(benzhydrylamino)ethylphosphinic acid

[1-(Benzhydrylidene-amino)-ethyl]-diethoxymethyl-phosphinic acid ethyl ester

formylacetic acid oxime

bis(trimethylsilyl)phosphonite

Downstream raw materials:

1-aminoethanephosphonic acid

[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

(L,D)-1-(N-phenylacetylamino)ethylphosphinic acid

C₁₃H₁₉N₂O₅P