N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N₂,N₂-diethyl-1,2-benzenedicarboxamide

Base Information

• Chemical Name: N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N₂,N₂-diethyl-1,2-benzenedicarboxamide
• CAS No.: 1207072-71-6
• Molecular Formula: C₂₅H₂₃ClF₆N₄O₂
• Molecular Weight: 560.927

Synonyms:N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N₂,N₂-diethyl-1,2-benzenedicarboxamide

Chemical Property of N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N₂,N₂-diethyl-1,2-benzenedicarboxamide

Chemical Property:

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Technology Process of N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N₂,N₂-diethyl-1,2-benzenedicarboxamide

There total 6 articles about N₁-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N₂,N₂-diethyl-1,2-benzenedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{[3,5-bis(trifluoro-methyl)-1H-pyrazol-1-yl]methyl}-2-methylaniline (866638-67-7) + 3-chloro-2-(diethylcarbamoyl)benzoylchloride (1207088-81-0) → N1-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N2,N2-diethyl-1,2-benzenedicarboxamide (1207072-71-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; Cooling with ice;

Reference yield:

3-chloro-2-(diethylcarbamoyl)-benzoic acid (1207088-80-9) → N1-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N2,N2-diethyl-1,2-benzenedicarboxamide (1207072-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 60 °C

2: triethylamine / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield:

3-chlorophthalic anhydride (117-21-5) → N1-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl]methyl}-2-methylphenyl)-3-chloro-N2,N2-diethyl-1,2-benzenedicarboxamide (1207072-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ISOPROPYLAMIDE / 1 h / -5 - 0 °C

1.2: 1 h / 0 °C

1.3: 5 °C / pH 4

2.1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 60 °C

3.1: triethylamine / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ISOPROPYLAMIDE; 1,2-dichloro-ethane;

upstream raw materials:

4-{[3,5-bis(trifluoro-methyl)-1H-pyrazol-1-yl]methyl}-2-methylaniline

3-chloro-2-(diethylcarbamoyl)benzoylchloride

4-(chloromethyl)-2-methyl-1-nitro-benzene

1-(3-methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole

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