[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

Base Information

Chemical Name:[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate
CAS No.:1611457-04-5
Molecular Formula:C₃₇H₃₇Cl₂N₃O₇
Molecular Weight:706.623
Hs Code.:

Synonyms:[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

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Chemical Property of [(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

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Technology Process of [(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

There total 10 articles about [(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1611455-23-2
2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid

: 25333-42-0
(R)-quinuclidin-3-ol

: 1611457-04-5
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

: 1611457-02-3
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1416002-37-3
(S)-(2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethyl)(R)-(2-(6-methoxynaphthalen-2-yl)propanoate)

: 1611457-04-5
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

: 1611457-02-3
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate; methanol / toluene / 24 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

3: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 20 °C

4: tin(II) chloride dihdyrate / tetrahydrofuran / 16 h / 75 °C

5: dichloromethane / 16 h / 20 °C

6: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With methanol; dmap; tin(II) chloride dihdyrate; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1416002-00-0
(S)-2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanol ?

: 1611457-04-5
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

: 1611457-02-3
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]amino]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

2: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 20 °C

3: tin(II) chloride dihdyrate / tetrahydrofuran / 16 h / 75 °C

4: dichloromethane / 16 h / 20 °C

5: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With dmap; tin(II) chloride dihdyrate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;