2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid

Base Information

Chemical Name:2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid
CAS No.:1611455-23-2
Molecular Formula:C₃₀H₂₆Cl₂N₂O₇
Molecular Weight:597.452
Hs Code.:

Synonyms:2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid

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Chemical Property of 2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid

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Technology Process of 2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid

There total 9 articles about 2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1611455-04-9
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate

: 298-12-4
Glyoxilic acid

: 98-80-6
phenylboronic acid

: 1611455-23-2
2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid

Guidance literature:: In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1611455-23-2
2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: methanol; chloroform / 2 h / 20 °C

4.1: potassium tert-butylate; methanol / toluene / 24 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

6.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 20 °C

7.1: tin(II) chloride dihdyrate / tetrahydrofuran / 16 h / 75 °C

8.1: dichloromethane / 16 h / 20 °C

With methanol; dmap; tin(II) chloride dihdyrate; potassium tert-butylate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1415994-42-1
(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethanol

: 1611455-23-2
2-[3-[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy-carbonyl]anilino]-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 20 °C

2: tin(II) chloride dihdyrate / tetrahydrofuran / 16 h / 75 °C

3: dichloromethane / 16 h / 20 °C

With dmap; tin(II) chloride dihdyrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane;