2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim

Base Information

• Chemical Name: 2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim
• CAS No.: 76441-48-0
• Molecular Formula: C₁₁H₁₅NOS
• Molecular Weight: 209.312
• Mol file: 76441-48-0.mol

Synonyms:2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim

Chemical Property of 2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim

There total 8 articles about 2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-Methyl-2-(3-thienyl)-1-cyclohexanon (76441-47-9) → 2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim (76441-48-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 0.666667h;

DOI:10.1002/ardp.19803131011

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim (76441-48-0)

Guidance literature:

Multi-step reaction with 8 steps

1: diethyl ether / 2 h / -70 °C

2: oxalic acid / toluene

3: 52.4 percent / amyl nitrite, 30percent aq. HCl / 3 h / -10 °C

4: 45.8 percent / 1.) pyridine / 1.) 70 deg C, 2.5 h, 2.) room temp., 15 h

5: 82.5 percent / 10percent aq. H₂SO₄ / 1.5 h / Heating

6: 99 percent / H₂ / Pd/C / dioxane / 0.25 h

7: 100 percent / 1.) NaH / 1.) benzene, reflux, 5 h, 2.) 45 deg C, 15 h

8: 71 percent / NH₂OH*HCl, NaAc / aq. ethanol / 0.67 h

With pyridine; hydrogenchloride; n-Amyl nitrite; sulfuric acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; oxalic acid; sodium hydride; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; toluene;

DOI:10.1002/ardp.19803131011

Reference yield:

1-(3-thiophene-yl)cyclohexene (76441-42-4) → 2-Methyl-2-(3-thienyl)-1-cyclohexanon-oxim (76441-48-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 52.4 percent / amyl nitrite, 30percent aq. HCl / 3 h / -10 °C

2: 45.8 percent / 1.) pyridine / 1.) 70 deg C, 2.5 h, 2.) room temp., 15 h

3: 82.5 percent / 10percent aq. H₂SO₄ / 1.5 h / Heating

4: 99 percent / H₂ / Pd/C / dioxane / 0.25 h

5: 100 percent / 1.) NaH / 1.) benzene, reflux, 5 h, 2.) 45 deg C, 15 h

6: 71 percent / NH₂OH*HCl, NaAc / aq. ethanol / 0.67 h

With pyridine; hydrogenchloride; n-Amyl nitrite; sulfuric acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; sodium hydride; palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1002/ardp.19803131011

upstream raw materials:

2-Methyl-2-(3-thienyl)-1-cyclohexanon

cyclohexanone

1-(3-thiophene-yl)cyclohexene

2-(3-Thienyl)-2-cyclohexen-1-on

Downstream raw materials:

trans-2-Methyl-2-(3-thienyl)-1-cyclohexylamin

(+)-cis-2-Methyl-2-(3-thienyl)-1-cyclohexylamin