4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide

Base Information

Chemical Name:4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide
CAS No.:1269421-71-7
Molecular Formula:C₂₇H₂₆ClFN₄O₅S
Molecular Weight:573.045
Hs Code.:

Synonyms:4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide

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Chemical Property of 4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide

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Technology Process of 4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide

There total 8 articles about 4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1093960-58-7
4-chloroquinazoline-8-carbonyl chloride

: 1269421-48-8
N-(3-amino-4-fluoro-2-methoxyphenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

: 1269421-71-7
4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide

Guidance literature:: With triethylamine; In chloroform; at 60 ℃; for 3.5h;

Reference yield:

: 83141-10-0
2,6-difluoro-3-nitrobenzoic acid

: 1269421-71-7
4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol / 2 h / Cooling with water bath

2.1: -4 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 60 h / 20 °C / 760.05 Torr / Inert atmosphere

4.1: dmap; pyridine / dichloromethane / 14.08 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

5.2: 3 h / 20 °C / Cooling with ice

6.1: sodium hydroxide; water / tetrahydrofuran / 48 h / 60 °C

6.2: pH 2

7.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere; Reflux

7.2: 2 h / Reflux

8.1: triethylamine / chloroform / 3.5 h / 60 °C

With pyridine; methanol; dmap; diphenyl phosphoryl azide; water; hydrogen; sodium hydride; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 84832-01-9
methyl 2,6-difluoro-3-nitrobenzoate

: 1269421-71-7
4-chloro-N-(6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)quinazoline-8-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: -4 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 60 h / 20 °C / 760.05 Torr / Inert atmosphere

3.1: dmap; pyridine / dichloromethane / 14.08 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

4.2: 3 h / 20 °C / Cooling with ice

5.1: sodium hydroxide; water / tetrahydrofuran / 48 h / 60 °C

5.2: pH 2

6.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere; Reflux

6.2: 2 h / Reflux

7.1: triethylamine / chloroform / 3.5 h / 60 °C

With pyridine; dmap; diphenyl phosphoryl azide; water; hydrogen; sodium hydride; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;