N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Base Information

Chemical Name:N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide
CAS No.:1360622-23-6
Molecular Formula:C₂₉H₂₈Cl₃F₂N₅O₃
Molecular Weight:638.929
Hs Code.:

N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Synonyms:N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

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Chemical Property of N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

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Technology Process of N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

There total 13 articles about N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360624-01-6
N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide

: C₁₆H₁₆ClF₂N₃O₂

: 1360622-23-6
N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide; C₁₆H₁₆ClF₂N₃O₂; at 20 ℃; for 2h;

With diisopropyl-carbodiimide; In acetonitrile; at 20 - 60 ℃;

Reference yield:

: C₂₉H₃₀Cl₃F₂N₅O₃S

: 1360622-23-6
N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: With diisopropyl-carbodiimide; In acetonitrile; at 20 - 60 ℃;

Reference yield:

: 601-88-7
2,6-dichloronitrobenzene

: 1360622-23-6
N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 75 °C

2.1: sodium hydroxide; methanol / 4 h / Reflux

3.1: triethylamine / tetrahydrofuran

4.1: hydrogen / Ra-Ni / tetrahydrofuran / 7 h / 2585.81 Torr

5.1: 1,4-dioxane / 10 h / 20 °C / Reflux

6.1: 2 h / 20 °C

6.2: 20 - 60 °C

With methanol; sulfuric acid; hydrogen; triethylamine; sodium hydroxide; Ra-Ni; In tetrahydrofuran; 1,4-dioxane;