N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide

Base Information

• Chemical Name: N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide
• CAS No.: 1360624-59-4
• Molecular Formula: C₁₄H₁₀ClF₂N₃O₃
• Molecular Weight: 341.702

Synonyms:N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide

Chemical Property of N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide

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Technology Process of N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide

There total 2 articles about N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-chloro-4-fluorophenylamine (367-21-5) + 2-fluoro-4-methylamino-5-nitro-benzoic acid (1242270-10-5) → N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide (1360624-59-4)

Guidance literature:

2-fluoro-4-methylamino-5-nitro-benzoic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; for 0.5h;

3-chloro-4-fluorophenylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;

Reference yield:

2,4-difluoro-5-nitro-benzoic acid (153775-33-8) → N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide (1360624-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water / 0.5 h / 20 °C / Cooling with ice

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h

2.2: 2 h

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; water;

Reference yield: 64.0%

2-fluoroethanol (371-62-0) + N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide (1360624-59-4) → N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide (1360624-58-3)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at 60 ℃; Cooling with ice;

upstream raw materials:

3-chloro-4-fluorophenylamine

2-fluoro-4-methylamino-5-nitro-benzoic acid

2,4-difluoro-5-nitro-benzoic acid

Downstream raw materials:

N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide

N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

N-(4-Fluoro-3-chloro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(4-fluoro-piperidinyl)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

N-(4-fluoro-3-chloro-phenyl)-2-(4-fluoro-piperidinyl)-4-methylamino-5-amino-benzoic acid amide

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