Technology Process of 3-(1H-indol-5-yl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrrolo-[2,3-b]pyridine
There total 6 articles about 3-(1H-indol-5-yl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrrolo-[2,3-b]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanol; sodium hydroxide;
In
acetone;
at 65 ℃;
for 0.5h;
- Guidance literature:
-
5-bromo-3-(1H-indol-5-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 3,4,5-trimethoxyphenylboronic Acid;
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
acetonitrile;
at 150 ℃;
for 0.166667h;
Inert atmosphere;
Microwave irradiation;
With
sodium hydroxide;
In
methanol; acetone;
at 65 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-iodo-succinimide / acetone / 0.33 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C
2.2: 1.5 h / 0 °C
3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 60 °C
4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation
5.1: sodium hydroxide / acetone; methanol / 0.5 h / 65 °C
With
N-iodo-succinimide; sodium hydride; sodium carbonate; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; acetone; acetonitrile; mineral oil;
