(-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid

Base Information

Chemical Name:(-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid
CAS No.:1202074-39-2
Molecular Formula:C₂₆H₂₄FN₃O₂S
Molecular Weight:461.56
Hs Code.:

Synonyms:(-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid

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Chemical Property of (-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid

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Technology Process of (-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid

There total 4 articles about (-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202077-72-2
ethyl 2-(diphenylmethyleneamino)-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoate

: 1202074-39-2
(-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 80 ℃; for 18h;
DOI:10.1016/j.bmcl.2011.12.073

Reference yield:

: 1202075-59-9
3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde

: 1202074-39-2
(-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 18 h / 35 °C

4.1: Chiralpak AD-H / liquid carbon dioxide; ethanol / Resolution of racemate

5.1: hydrogenchloride; water / tetrahydrofuran / 18 h / 80 °C

With hydrogenchloride; potassium tert-butylate; water; caesium carbonate; In tetrahydrofuran; ethanol; liquid carbon dioxide; N,N-dimethyl-formamide; 1.1: Peterson olefination / 2.1: Peterson olefination;
DOI:10.1016/j.bmcl.2011.12.073

Reference yield:

: C₂₆H₂₇FN₂OSSi

: 1202074-39-2
(-)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 18 h / 35 °C

3.1: Chiralpak AD-H / liquid carbon dioxide; ethanol / Resolution of racemate

4.1: hydrogenchloride; water / tetrahydrofuran / 18 h / 80 °C

With hydrogenchloride; potassium tert-butylate; water; caesium carbonate; In tetrahydrofuran; ethanol; liquid carbon dioxide; N,N-dimethyl-formamide; 1.1: Peterson olefination;
DOI:10.1016/j.bmcl.2011.12.073