tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane
CAS No.:157394-79-1
Molecular Formula:C₂₂H₃₀O₃Si
Molecular Weight:370.564
Hs Code.:

Synonyms:tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

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Chemical Property of tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

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Technology Process of tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

There total 4 articles about tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 158718-95-7
2(R)-methoxy-4(S)-<(tert-butyldiphenylsilyl)oxy>-2,3-dihydro-4H-pyran

: 157394-79-1
tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 23 ℃; for 10h; under 760 Torr; Yield given;
DOI:10.1016/S0040-4039(00)73170-4

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 157394-79-1
tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: AgNO₃, C₅H₅N / CH₂Cl₂ / 3 h / 23 °C

2: 1.) Tf₂O; 2.) DBU / 1.) C₅H₅N, CH₂Cl₂, 0 deg C, 2 h; 2.) 23 deg C, 10 h

3: H₂ / 10 percent Pd/C / ethyl acetate / 10 h / 23 °C / 760 Torr

With pyridine; trifluoromethylsulfonic anhydride; hydrogen; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)73170-4

Reference yield:

: 158719-05-2
(3R,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-3-ol

: 157394-79-1
tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Tf₂O; 2.) DBU / 1.) C₅H₅N, CH₂Cl₂, 0 deg C, 2 h; 2.) 23 deg C, 10 h

2: H₂ / 10 percent Pd/C / ethyl acetate / 10 h / 23 °C / 760 Torr

With trifluoromethylsulfonic anhydride; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/S0040-4039(00)73170-4