5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Base Information

Chemical Name:5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol
CAS No.:1609552-34-2
Molecular Formula:C₄₀H₃₆F₃N₅O₅
Molecular Weight:723.752
Hs Code.:

Synonyms:5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

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Chemical Property of 5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

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Technology Process of 5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

There total 3 articles about 5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 149540-21-6
5-(6-amino-8-bromo-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

: 460748-43-0
(E)-2-(4-fluorophenyl)vinylboronic acid

: 1609552-34-2
5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Guidance literature:: With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 90 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.03.081

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1609552-34-2
5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / pyridine / 5 h / 20 °C / Inert atmosphere

2: palladium diacetate; sodium carbonate; trisodium tris(3-sulfophenyl)phosphine / water; acetonitrile / 3 h / 90 °C / Inert atmosphere

With dmap; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; triethylamine; In pyridine; water; acetonitrile;
DOI:10.1016/j.ejmech.2014.03.081

Reference yield:

: 14985-44-5,90968-89-1
8-bromo-2'-deoxyadenosine

: 1609552-34-2
5-(6-amino-8-(4-(trifluoromethyl)styryl)-9H-purin-9-yl)-2-((bis(4-methoxy-phenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / pyridine / 5 h / 20 °C / Inert atmosphere

2: palladium diacetate; sodium carbonate; trisodium tris(3-sulfophenyl)phosphine / water; acetonitrile / 3 h / 90 °C / Inert atmosphere

With dmap; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; triethylamine; In pyridine; water; acetonitrile;
DOI:10.1016/j.ejmech.2014.03.081