Boronic acid, [(1E)-2-(4-fluorophenyl)ethenyl]-

Base Information

• Chemical Name: Boronic acid, [(1E)-2-(4-fluorophenyl)ethenyl]-
• CAS No.: 460748-43-0
• Molecular Formula: C8H8BFO2
• Molecular Weight: 165.96
• Mol file: 460748-43-0.mol

Synonyms:trans-2-(4-fluorophenyl)ethenylboronic acid;[(E)-2-(4-fluorophenyl)vinyl]boronic acid;trans-2-(4-fluoro-phenyl)vinylboronic acid;4-trans-2-(4-fluorophenyl)vinylboronic acid;[(E)-2-(4-fluorophenyl)ethenyl]boronic acid;trans-2-(4-fluorophenyl) vinyl boronic acid;

Chemical Property of Boronic acid, [(1E)-2-(4-fluorophenyl)ethenyl]-

Chemical Property:

• PSA: 40.46000
• LogP: 0.85090

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boronic acid, [(1E)-2-(4-fluorophenyl)ethenyl]-

There total 8 articles about Boronic acid, [(1E)-2-(4-fluorophenyl)ethenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-ethynyl-4-fluorobenzene (766-98-3) + benzo[1,3,2]dioxaborole (274-07-7) → (E)-2-(4-fluorophenyl)vinylboronic acid (460748-43-0)

Guidance literature:

1-ethynyl-4-fluorobenzene; benzo[1,3,2]dioxaborole; In tetrahydrofuran; for 18h; Reflux;

With water; at 20 ℃; for 4h;

Reference yield:

7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile (938465-55-5) + 4-trifluoromethylphenylboronic acid (128796-39-4) → (E)-2-(4-fluorophenyl)vinylboronic acid (460748-43-0)

Guidance literature:

With sodium carbonate; triphenylphosphine; palladium diacetate; In propan-1-ol; water; at 100 ℃; for 3h;

Reference yield:

1-ethynyl-4-fluorobenzene (766-98-3) → (E)-2-(4-fluorophenyl)vinylboronic acid (460748-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 70 °C

2: water

With water; In tetrahydrofuran;

DOI:10.1071/CH10341

upstream raw materials:

7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile

4-trifluoromethylphenylboronic acid

1-ethynyl-4-fluorobenzene

4-FC₆H₄CH=CH(Bcat)

Downstream raw materials:

C₂₂H₂₆FN₃O₃

(1E,3E)-1,4-bis(4-fluorophenyl)buta-1,3-diene

methyl 6-[(2E)-3-(4-fluorophenyl)prop-2-enoyl]-1,2,3,4-tetrahydropyridine-1-carboxylate