C₅₃H₈₄BrNO₁₀Si₂

Base Information

• Chemical Name: C₅₃H₈₄BrNO₁₀Si₂
• CAS No.: 552850-01-8
• Molecular Formula: C₅₃H₈₄BrNO₁₀Si₂
• Molecular Weight: 1031.33
• Mol file: 552850-01-8.mol

Synonyms:C₅₃H₈₄BrNO₁₀Si₂

Chemical Property of C₅₃H₈₄BrNO₁₀Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₃H₈₄BrNO₁₀Si₂

There total 49 articles about C₅₃H₈₄BrNO₁₀Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C55H90BrNO11Si2 (552850-11-0) → C53H84BrNO10Si2 (552850-01-8)

Guidance literature:

With dimethylboron bromide; In diethyl ether; at -78 ℃;

DOI:10.1002/anie.200390321

Reference yield:

(4E)(2R)-1-(benzothiazol-2-ylsulfonyl)-5-bromo-2-(methoxy)-pent-4-ene (296785-24-5) → C53H84BrNO10Si2 (552850-01-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 93 percent / NaHMDS / tetrahydrofuran / 5 h / -78 - 20 °C

2.1: 98 percent / Me₂BBr / CH₂Cl₂; dimethyl ether / 1.5 h / -78 °C

3.1: 82 percent / TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 24 h / 20 °C

4.1: n-BuLi; Et₂NH / hexane; tetrahydrofuran / 0.2 h / -78 °C

4.2: hexane; tetrahydrofuran / 0.5 h / -78 °C

5.1: pyridine / acetonitrile; diethyl ether / 36 h / -47 °C

6.1: 85 percent / Me₂BBr / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

With pyridine; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; dimethylboron bromide; 4 A molecular sieve; sodium hexamethyldisilazane; diethylamine; In tetrahydrofuran; diethyl ether; hexane; Dimethyl ether; dichloromethane; acetonitrile; 1.1: Julia reaction;

DOI:10.1039/b308305e

Reference yield:

(4R,5R,7R)-4-(tert-butyl-dimethyl-silanyloxy)-7,9,9-trimethoxy-5-(4'-methoxy-benzyloxy)-2-methyl-non-(2E)-enal (213978-44-0) → C53H84BrNO10Si2 (552850-01-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 93 percent / NaHMDS / tetrahydrofuran / 5 h / -78 - 20 °C

2.1: 98 percent / Me₂BBr / CH₂Cl₂; dimethyl ether / 1.5 h / -78 °C

3.1: 82 percent / TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 24 h / 20 °C

4.1: n-BuLi; Et₂NH / hexane; tetrahydrofuran / 0.2 h / -78 °C

4.2: hexane; tetrahydrofuran / 0.5 h / -78 °C

5.1: pyridine / acetonitrile; diethyl ether / 36 h / -47 °C

6.1: 85 percent / Me₂BBr / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

With pyridine; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; dimethylboron bromide; 4 A molecular sieve; sodium hexamethyldisilazane; diethylamine; In tetrahydrofuran; diethyl ether; hexane; Dimethyl ether; dichloromethane; acetonitrile; 1.1: Julia reaction;

DOI:10.1039/b308305e

upstream raw materials:

C₅₅H₉₀BrNO₁₁Si₂

D-xylose

D-xylose diethyl dithioacetal

2-deoxy-4,5-O-isopropylidene-D-threo-pentose diethyl dithioacetal

Refernces

• 1、 Pattenden, Gerald,Gonzalez, Miguel A,Little, Paul B,Millan, David S,Plowright, Alleyn T,Tornos, James A,Ye, Tao. "Total synthesis of (+)-phorboxazole A, a potent cytostatic agent from the sponge Phorbas sp.". . p. 4173 - 4208. Retrieved 2007/10/03.