Technology Process of MIDA (1-hydroxy-2-oxo-2-phenylethyl)boronate
There total 5 articles about MIDA (1-hydroxy-2-oxo-2-phenylethyl)boronate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(Z)-MIDA (2-phenyl-1-((trimethylsilyl)oxy)vinyl)boronate;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 23 ℃;
for 2h;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 2 ℃;
for 1h;
DOI:10.1002/anie.201206501
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Dess-Martin periodane / dichloromethane; water / 23 °C
2.1: dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 23 °C
3.2: 1 h / 2 °C
With
dmap; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; water;
1.1: |Dess-Martin Oxidation / 3.1: |Rubottom Oxidation;
DOI:10.1002/anie.201206501
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h / 23 °C / Inert atmosphere; Darkness
2.1: 2-methylpropan-2-thiol; oxygen / dichloromethane / 23 °C / Irradiation
2.2: 2 h / 23 °C
3.1: Dess-Martin periodane / dichloromethane; water / 23 °C
4.1: dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 23 °C
5.2: 1 h / 2 °C
With
dmap; oxygen; Dess-Martin periodane; 2-methylpropan-2-thiol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide;
In
dichloromethane; water;
3.1: |Dess-Martin Oxidation / 5.1: |Rubottom Oxidation;
DOI:10.1002/anie.201206501
