Technology Process of rac-3'-(6-amino-2,4-dimethyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-biphenyl-3-carbonitrile
There total 11 articles about rac-3'-(6-amino-2,4-dimethyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-biphenyl-3-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; ethanol;
at 150 ℃;
for 0.333333h;
Inert atmosphere;
Micriwave irradiatoin;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: hydrogenchloride / 96 h / Reflux
1.2: 20 °C / pH 8
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C
3.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C
3.2: pH 1 - 2 / Cooling with ice
4.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C
5.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C
5.2: 5 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice
7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
8.1: dichloromethane / 72 h / 20 °C
9.1: ammonium chloride / ethanol / 18 h / 75 °C
10.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; ethanol / 0.33 h / 150 °C / Inert atmosphere; Micriwave irradiatoin
With
hydrogenchloride; lithium aluminium tetrahydride; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C
1.2: pH 1 - 2 / Cooling with ice
2.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C
3.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C
3.2: 5 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice
5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
6.1: dichloromethane / 72 h / 20 °C
7.1: ammonium chloride / ethanol / 18 h / 75 °C
8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; ethanol / 0.33 h / 150 °C / Inert atmosphere; Micriwave irradiatoin
With
hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;
