(Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile

Base Information

Chemical Name:(Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile
CAS No.:119999-30-3
Molecular Formula:C₂₄H₂₇N
Molecular Weight:329.485
Hs Code.:

Synonyms:(Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile

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Chemical Property of (Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile

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Technology Process of (Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile

There total 11 articles about (Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 853998-14-8
4,4,5,5-tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane

: 853998-15-9
(Z)-1-bromo-2-(4-cyanophenyl)propene

: 119999-30-3
(Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 80 ℃; for 20h;
DOI:10.1016/j.tet.2005.03.023

Reference yield: 50.0%

: 623-00-7
4-bromobenzenecarbonitrile

: (E)-(1,3-dimethyl-1H-imidazol-3-ium-2-yl)(1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-2-yl)dihydroborate

: 119999-30-3
(Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile

Guidance literature:: (E)-(1,3-dimethyl-1H-imidazol-3-ium-2-yl)(1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-2-yl)dihydroborate; With N-chloro-succinimide; In 1,4-dioxane; at 20 ℃; for 0.25h;

4-bromobenzenecarbonitrile; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium carbonate; for 3h; Reflux;
DOI:10.1002/anie.201804515

Reference yield:

: 652997-73-4
(E)-3-(4-cyanophenyl)-but-2-enoic acid ethyl ester

: 119999-30-3
(Z)-4-<1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl>benzenecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 25 g / potassium hydroxide / methanol / 20 °C

2.1: bromine / CHCl₃ / 12 h

2.2: 88 percent / NaHCO₃ / acetone / 16 h / Heating

3.1: 72 percent / NaHCO₃ / Pd(dppf)Cl₂ / H₂O; dioxane / 20 h / 80 °C

With potassium hydroxide; bromine; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; chloroform; water; 3.1: Suzuki cross-coupling;
DOI:10.1016/j.tet.2005.03.023