(R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one

Base Information

• Chemical Name: (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one
• CAS No.: 126884-67-1
• Molecular Formula: C₁₉H₂₉NO₆
• Molecular Weight: 367.442

Synonyms:(R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one

Chemical Property of (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one

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Technology Process of (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one

There total 8 articles about (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylmagnesium bromide (75-16-1) + (2R,5R)-N-benzoylcarbonyl-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine (115378-72-8) → methyllithium (917-54-4) + (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one (126884-67-1)

Guidance literature:

In tetrahydrofuran; at -80 - 35 ℃; Product distribution; effect of temperature and solvent on diastereomeric excess;

Reference yield:

phenyllithium (591-51-5) + (2R,5R)-N-acetylcarbonyl-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine (115378-74-0) → (S)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one (126884-68-2) + (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one (126884-67-1)

Guidance literature:

In tetrahydrofuran; at -78 ℃; Yield given. Yields of byproduct given;

Reference yield:

methyllithium (917-54-4) + (2R,5R)-N-benzoylcarbonyl-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine (115378-72-8) → (S)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one (126884-68-2) + (R)-1-((2R,5R)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-hydroxy-2-phenyl-propan-1-one (126884-67-1)

Guidance literature:

In diethyl ether; Yield given. Yields of byproduct given; Ambient temperature;

upstream raw materials:

methyllithium

(2R,5R)-N-benzoylcarbonyl-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine

methylmagnesium bromide

(2R,5R)-N-acetylcarbonyl-trans-2,5-bis(methoxymethoxymethyl)pyrrolidine

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