5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one

Base Information

• Chemical Name: 5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one
• CAS No.: 910484-16-1
• Molecular Formula: C₁₆H₁₀F₆N₂O₂
• Molecular Weight: 376.258
• Mol file: 910484-16-1.mol

Synonyms:5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one

Chemical Property of 5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one

There total 4 articles about 5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H7Cl3F3NO3 + 3,3,3-trifluoropropylamine (460-39-9) → N-[3,4-difluoro-2-(4-fluorobenzoyl)phenyl]-N'-(2,2,2-trifluoroethyl)urea (910484-15-0) + 5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one (910484-16-1)

Guidance literature:

With triethylamine; In diethyl ether; at 0 - 20 ℃; for 5h;

Reference yield:

(6-amino-2,3-difluorophenyl)(4-fluorophenyl)methanone (910484-14-9) + trifluoroethylamine (753-90-2) → N-[3,4-difluoro-2-(4-fluorobenzoyl)phenyl]-N'-(2,2,2-trifluoroethyl)urea (910484-15-0) + 5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one (910484-16-1)

Guidance literature:

(6-amino-2,3-difluorophenyl)(4-fluorophenyl)methanone; With bis(trichloromethyl) carbonate; triethylamine; In diethyl ether; at 0 ℃; for 1h;

trifluoroethylamine; With triethylamine; In diethyl ether; at 20 ℃;

Reference yield:

N-[3,4-difluoro-2-(4-fluorobenzoyl)phenyl]-N'-(2,2,2-trifluoroethyl)urea (910484-15-0) → 5,6-difluoro-4-(4-fluorophenyl)-4-hydroxy-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one (910484-16-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 80 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

N-[3,4-difluoro-2-(4-fluorobenzoyl)phenyl]-N'-(2,2,2-trifluoroethyl)urea

3,3,3-trifluoropropylamine

(6-amino-2,3-difluorophenyl)(4-fluorophenyl)methanone

trifluoroethylamine

Downstream raw materials:

C₁₉H₁₆F₆N₂O