2-AMINO-5-BROMO-3-METHYLPYRAZINE

Base Information

• Chemical Name: 2-AMINO-5-BROMO-3-METHYLPYRAZINE
• CAS No.: 74290-67-8
• Molecular Formula: C5H6BrN3
• Molecular Weight: 188.027
• Hs Code.: 2933990090
• Mol file: 74290-67-8.mol

Synonyms:2-Amino-5-bromo-3-methylpyrazine;5-Bromo-3-methylpyrazin-2-amine;Pyrazinamine,5-bromo-3-methyl- (9CI);

Chemical Property of 2-AMINO-5-BROMO-3-METHYLPYRAZINE

Chemical Property:

• Boiling Point: 272.381 °C at 760 mmHg
• PKA: 2.00±0.10(Predicted)
• Flash Point: 118.532 °C
• PSA: 51.80000
• Density: 1.7 g/cm³
• LogP: 1.71090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-5-bromo-3-methylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-BROMO-3-METHYLPYRAZINE

There total 1 articles about 2-AMINO-5-BROMO-3-METHYLPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

amino-2 methyl-3 pyrazine (19838-08-5) → 2-amino-5-bromo-3-methylpyrazine (74290-67-8)

Guidance literature:

With pyridine; bromine; In chloroform; for 0.5h; Ambient temperature; in the dark;

Reference yield: 100.0%

2-amino-5-bromo-3-methylpyrazine (74290-67-8) → amino-2 methyl-3 pyrazine (19838-08-5)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; at 25 ℃; for 0.666667h;

Reference yield: 49.8%

2-amino-5-bromo-3-methylpyrazine (74290-67-8) + phenol (108-95-2,27073-41-2) → 3-methyl-5-phenoxypyrazin-2-amine

Guidance literature:

With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate; In 1,4-dioxane; at 90 ℃; for 12h; Inert atmosphere;

upstream raw materials:

amino-2 methyl-3 pyrazine

Downstream raw materials:

amino-2 methyl-3 pyrazine

5-(4-{(R)-1-Cyclopropyl-1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-ethyl}-phenyl)-3-methyl-pyrazin-2-ylamine

phenyl N-[5-(dimethylamino)-3-methylpyrazin-2-yl]carbamate

Refernces

• 1、 -. "N-heterocyclyl sulphonamide derivatives and their use as endothelin antagonists". . . Retrieved 2008/06/13.