19838-08-5

Basic information

• Product Name: 2-Amino-3-methylpyrazine
• Synonyms: 3-METHYLPYRAZIN-2-YLAMINE;2-AMINO-3-METHYLPYRAZINE;3-methylpyrazin-2-amine;3-Methyl-2-pyrazinamine;2-Methyl-3-aMinopyrazine;2-Pyrazinamine,3-methyl-
• CAS NO: 19838-08-5
• Molecular Formula: C₅H₇N₃
• Molecular Weight: 109.13
• Product Categories: Piperazines
• Mol File: 19838-08-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 165-167 °C
• Boiling Point: 194.6°C (rough estimate)
• Flash Point: 123.7 °C
• Appearance: /Solid
• Density: 1.1118 (rough estimate)
• Vapor Pressure: 0.0337mmHg at 25°C
• Refractive Index: 1.5340 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.56±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-methylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-methylpyrazine(19838-08-5)
• EPA Substance Registry System: 2-Amino-3-methylpyrazine(19838-08-5)

Safety Data

• Hazardous Substances Data: 19838-08-5(Hazardous Substances Data)

Usage

General Description

2-Amino-3-methylpyrazine is a chemical compound that belongs to the class of organic compounds known as pyrazines, which are polycyclic aromatic compounds containing a pyrazine ring, a six-membered aromatic heterocycle made up of two nitrogen atoms (at positions 1 and 4) and four carbon atoms. It is commonly used in the food industry as a flavoring agent due to its nutty and roasted taste. In addition, it occurs naturally in a variety of toasted, roasted and grilled food products such as coffee, popcorn, and roasted chicken.

InChI:InChI=1/C5H7N3/c1-4-5(6)8-3-2-7-4/h2-3H,1H3,(H2,6,8)

Upstream product

• 95-58-9 2-chloro-3-methylpyrazine 
• 74290-67-8 2-amino-5-bromo-3-methylpyrazine 

Downstream Products

• 74290-67-8 2-amino-5-bromo-3-methylpyrazine 
• 103965-75-9 2-methylpyrazine 1-oxide 
• 103965-76-0 2-methylpyrazine 4-oxide 
• 91416-90-9 5-iodo-3-methylpyrazin-2-amine 
• 1610528-89-6 1-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea 
• 1610529-37-7 8-methyl-2-phenyl-N-(2,4,4-trimethylpentan-2-yl)imidazo[1,2-a]pyrazin-3-amine 
• 1020326-34-4 phenyl 3-methylpyrazin-2-ylcarbamate 

Relevant articles and documents

Preparation method of 2 (2-ethoxy-2-oxoethyl)-8-methyl-5, 6-dihydroimidazo pyrazine carboxylic acid tert-butyl ester

The invention relates to a synthesizing method of 2 (2-ethoxy-2-oxoethyl)-8-methyl-5, 6-dihydroimidazo [1, 2-a] pyrazine-7 (8H)-carboxylic acid tert-butyl ester, and aims at solving the technical problem that a proper industrial synthesizing method is not provided currently. The method comprises the following four steps: 1, reacting a compound 1 and ammonium hydroxide in a high-pressure kettle to obtain a compound 2; 2, reacting the compound 2 and 4-epoxide-2-ethyl crotonate through acetonitrile to obtain a compound 3; 3, hydrogenating the compound 3 through a catalyst which is palladium/carbon in methanol to obtain a compound 4; and 4, adding Boc anhydride and potassium carbonate to the compound 4 in ethyl alcohol; and reacting overnight at room temperature to obtain a final compound 5.

4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS

Novel compounds of formulae (II, III) and pharmaceutical compositions have been found to inhibit inducible NOS synthase wherein: R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, lower alkyl, and halogen; and, R8 has the structure whrein X1, X2, X3, X4, X5, X6, R9, R13, R14 and n are as described herein.

ANGIOGENESIS INHIBITORS

The present invention relates to the use of compounds for the treatment of angiogenesis related disorders involving a protein kinase as a medicament. The compounds e.g. have the general formula I. In preferred embodiments Rl and R5 are independently selec