2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile

Base Information

Chemical Name:2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile
CAS No.:1364674-23-6
Molecular Formula:C₁₈H₁₃Cl₃F₃N₃
Molecular Weight:434.676
Hs Code.:

Synonyms:2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile

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Chemical Property of 2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile

Chemical Property:

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Technology Process of 2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile

There total 4 articles about 2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364674-22-5
3-bromo-2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]pyridine

: copper(l) cyanide

: 1364674-23-6
2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile

Guidance literature:: With 1-methyl-pyrrolidin-2-one; at 200 ℃; for 4h; microwave reactor;

Reference yield:

: 18368-63-3
6-chloro-2-picoline

: 1364674-23-6
2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 1 h / 120 °C / microwave reactor

2: bromine; sodium carbonate / dichloromethane; water / 1 h / 0 °C

3: 1-methyl-pyrrolidin-2-one / 4 h / 200 °C / microwave reactor

With 1-methyl-pyrrolidin-2-one; bromine; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In dichloromethane; water; toluene;

Reference yield:

: 1072916-25-6
3-(3,4,5-trichloro-phenyl)-3-trifluoromethyl-pyrrolidine

: 1364674-23-6
2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 1 h / 120 °C / microwave reactor

2: bromine; sodium carbonate / dichloromethane; water / 1 h / 0 °C

3: 1-methyl-pyrrolidin-2-one / 4 h / 200 °C / microwave reactor

With 1-methyl-pyrrolidin-2-one; bromine; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In dichloromethane; water; toluene;