(S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

Base Information

Chemical Name:(S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide
CAS No.:1434722-83-4
Molecular Formula:C₁₇H₂₇ClFNO₂SSi
Molecular Weight:392.01
Hs Code.:

Synonyms:(S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

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Chemical Property of (S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

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Technology Process of (S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

There total 8 articles about (S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1434722-71-0
3-tert-butyldimethylsilanyloxy-4-chloro-2-fluorobenzaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 1434722-83-4
(S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

Guidance literature:: With titanium(IV) tetraethanolate; In dichloromethane;

Reference yield:

: 1434722-60-7
acetic acid 6-chloro-3-dibromomethyl-2-fluoro-phenyl ester

: 1434722-83-4
(S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

Guidance literature:: Multi-step reaction with 4 steps

1: silver nitrate / isopropyl alcohol; water / 1 h / 32 °C

2: sodium hydroxide / methanol / 1 h / 50 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4: titanium(IV) tetraethanolate / dichloromethane

With 1H-imidazole; titanium(IV) tetraethanolate; silver nitrate; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 261762-91-8
6-chloro-2-fluoro-3-methylphenol

: 1434722-83-4
(S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 1 h / 50 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

3: silver nitrate / isopropyl alcohol; water / 1 h / 32 °C

4: sodium hydroxide / methanol / 1 h / 50 °C

5: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

6: titanium(IV) tetraethanolate / dichloromethane

With pyridine; 1H-imidazole; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver nitrate; sodium hydroxide; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;