(S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide

Base Information

Chemical Name:(S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide
CAS No.:1434722-86-7
Molecular Formula:C₂₀H₃₃ClFNO₂SSi
Molecular Weight:434.09
Hs Code.:

Synonyms:(S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide

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Chemical Property of (S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide

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Technology Process of (S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide

There total 9 articles about (S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1434722-83-4
(S)-2-methyl-propane-2-sulfinic acid (E)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-methylideneamide

: 23719-80-4
cyclopropylmagnesium bromide

: 1434722-86-7
(S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide

Guidance literature:: In tetrahydrofuran; at -65 ℃; for 1.5h;

Reference yield:

: 1434722-54-9
acetic acid 6-chloro-2-fluoro-3-methyl-phenyl ester

: 1434722-86-7
(S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

2: silver nitrate / isopropyl alcohol; water / 1 h / 32 °C

3: sodium hydroxide / methanol / 1 h / 50 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

5: titanium(IV) tetraethanolate / dichloromethane

6: tetrahydrofuran / 1.5 h / -65 °C

With 1H-imidazole; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver nitrate; sodium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1434722-60-7
acetic acid 6-chloro-3-dibromomethyl-2-fluoro-phenyl ester

: 1434722-86-7
(S)-2-methyl-propane-2-sulfinic acid {(R)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-chloro-2-fluoro-phenyl]-cyclopropyl-methyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: silver nitrate / isopropyl alcohol; water / 1 h / 32 °C

2: sodium hydroxide / methanol / 1 h / 50 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4: titanium(IV) tetraethanolate / dichloromethane

5: tetrahydrofuran / 1.5 h / -65 °C

With 1H-imidazole; titanium(IV) tetraethanolate; silver nitrate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;