N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide

Base Information

Chemical Name:N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide
CAS No.:1394002-09-5
Molecular Formula:C₂₄H₂₅ClFN₃O₃
Molecular Weight:457.932
Hs Code.:

Synonyms:N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide

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Chemical Property of N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide

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Technology Process of N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide

There total 3 articles about N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394002-25-5
C₁₈H₁₂ClFN₂O₃

: 108-91-8,157973-60-9
cyclohexylamine

: 1394002-09-5
N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide

Guidance literature:: In acetonitrile; at 20 ℃;
DOI:10.1016/j.ejmech.2012.06.001

Reference yield:

: 459-23-4,7304-35-0
(E)-4-fluorobenzaldehyde oxime

: 1394002-09-5
N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; N-chloro-succinimide / chloroform / 20 °C / Inert atmosphere; Cooling with ice

2: pyridine; methanesulfonyl chloride / acetonitrile / 20 °C

3: acetonitrile / 20 °C

With pyridine; N-chloro-succinimide; methanesulfonyl chloride; In chloroform; acetonitrile;
DOI:10.1016/j.ejmech.2012.06.001

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1394002-09-5
N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 45 - 50 °C

2: pyridine; N-chloro-succinimide / chloroform / 20 °C / Inert atmosphere; Cooling with ice

3: pyridine; methanesulfonyl chloride / acetonitrile / 20 °C

4: acetonitrile / 20 °C

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; methanesulfonyl chloride; In ethanol; chloroform; acetonitrile;
DOI:10.1016/j.ejmech.2012.06.001