Technology Process of 4-((4R,5S,6S)-6-(benzyloxymethyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutanal
There total 14 articles about 4-((4R,5S,6S)-6-(benzyloxymethyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 0 - 20 ℃;
for 1.08333h;
Inert atmosphere;
DOI:10.1021/jacs.9b05013
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / methanol / 1.33 h / -78 °C / Inert atmosphere
1.2: 0.17 h / -78 - 20 °C / Inert atmosphere
2.1: pyridinium p-toluenesulfonate / dichloromethane / 24.67 h / 0 - 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
4.1: Dess-Martin periodane / dichloromethane / 1.08 h / 0 - 20 °C / Inert atmosphere
With
sodium tetrahydroborate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; Dess-Martin periodane; acetic acid;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
4.1: Dess-Martin oxidation;
DOI:10.1002/anie.201102521
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
2: Dess-Martin periodane / dichloromethane / 1.08 h / 0 - 20 °C / Inert atmosphere
With
tetrabutyl ammonium fluoride; Dess-Martin periodane; acetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
2: Dess-Martin oxidation;
DOI:10.1002/anie.201102521
