(4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane

Base Information

Chemical Name:(4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane
CAS No.:1333237-30-1
Molecular Formula:C₃₄H₄₃Cl₃O₄Si
Molecular Weight:650.158
Hs Code.:

Synonyms:(4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane

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Chemical Property of (4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane

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Technology Process of (4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane

There total 13 articles about (4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 116-11-0
2-Methoxypropene

: 1333237-29-8
(2S,3S,4R)-1-(benzyloxy)-8-((tert-butyldiphenylsilyl)oxy)-3,5,5-trichlorooctane-2,4-diol

: 1333237-30-1
(4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 0 - 20 ℃; for 24.6667h; Inert atmosphere;
DOI:10.1002/anie.201102521

Reference yield:

: 1333237-28-7
(2S,3S)-1-(benzyloxy)-8-(tert-butyldiphenylsilyloxy)-3,5,5-trichloro-2-hydroxyoctan-4-one

: 1333237-30-1
(4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 1.33 h / -78 °C / Inert atmosphere

1.2: 0.17 h / -78 - 20 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / dichloromethane / 24.67 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; pyridinium p-toluenesulfonate; In methanol; dichloromethane;
DOI:10.1002/anie.201102521

Reference yield:

: 1333237-27-6
1-((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)-5-((tert-butyldiphenylsilyl)oxy)-2,2-dichloropentan-1-one

: 1333237-30-1
(4-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-4,4-dichlorobutoxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: zirconium(IV) chloride / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

1.2: 0.08 h / 0 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 1.33 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 - 20 °C / Inert atmosphere

3.1: pyridinium p-toluenesulfonate / dichloromethane / 24.67 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; pyridinium p-toluenesulfonate; zirconium(IV) chloride; In methanol; dichloromethane;
DOI:10.1002/anie.201102521