(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:171564-50-4
Molecular Formula:C₃₁H₄₇NO₇SSi
Molecular Weight:605.868
Hs Code.:

(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Synonyms:(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of (4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of (4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 9 articles about (4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 158584-94-2
(4R,5R)-3-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethyl-5-<3''-hydroxypropyl>-2,2-dimethyl-1,3-oxazolidine

: 171564-50-4
(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1021/ja00097a072

Reference yield:

: 95715-85-8
2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester

: 171564-50-4
(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / imidazole / dimethylformamide / 14 h / 25 °C

2: DIBALH / toluene / 0.5 h / -78 °C

4: CSA / CH₂Cl₂ / 3 h / 25 °C

5: 1.) 9-BBN, 2.) 3 N aq. NaOH, 30percent H₂O₂ / 1.) THF, 25 deg C, 20 h, 2.) MeOH, 25 deg C, 5 h

6: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

With 1H-imidazole; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; camphor-10-sulfonic acid; dihydrogen peroxide; diisobutylaluminium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 158584-92-0
[(1R,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester

: 171564-50-4
(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(3-methanesulfonyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CSA / CH₂Cl₂ / 3 h / 25 °C

2: 1.) 9-BBN, 2.) 3 N aq. NaOH, 30percent H₂O₂ / 1.) THF, 25 deg C, 20 h, 2.) MeOH, 25 deg C, 5 h

3: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; camphor-10-sulfonic acid; dihydrogen peroxide; triethylamine; In dichloromethane;