tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate

Base Information

Chemical Name:tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate
CAS No.:1295567-73-5
Molecular Formula:C₂₆H₂₆F₂IN₃O₅S
Molecular Weight:657.477
Hs Code.:

Synonyms:tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate

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Chemical Property of tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate

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Technology Process of tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate

There total 5 articles about tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1295567-72-4
tert-butyl (3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate

: 139631-62-2
cyclopropanesulfonyl chloride

: 1295567-73-5
tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate

Guidance literature:: With pyridine; for 16h;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295567-73-5
tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 0 °C

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: sodium dithionite / tetrahydrofuran / 1 h / 50 °C

4: pyridine / 16 h

With pyridine; sodium dithionite; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 765962-75-2
3,5-difluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline

: 1295567-73-5
tert-butyl (3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: sodium dithionite / tetrahydrofuran / 1 h / 50 °C

3: pyridine / 16 h

With pyridine; sodium dithionite; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;