tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate

Base Information

• Chemical Name: tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate
• CAS No.: 528868-63-5
• Molecular Formula: C₁₇H₂₄N₂O₃
• Molecular Weight: 304.389
• Mol file: 528868-63-5.mol

Synonyms:tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate

Chemical Property of tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate

There total 1 articles about tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methylmagnesium bromide (75-16-1) + 1-benzyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester (434331-98-3) → 2-benzyl-6-(1-hydroxy-1-methylethyl)-4,5-dihydropyridazin-3(2H)-one + tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate (528868-63-5)

Guidance literature:

With ytterbium(III) triflate; In diethyl ether; toluene; at -50 ℃; for 24h;

DOI:10.1002/1099-0690(200212)2002:24<4190::AID-EJOC4190>3.0.CO;2-Q

Reference yield: 85.0%

tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate (528868-63-5) → tert-butyl 1-benzylideneamino-2-methyl-5-oxopyrrolidine-2-carboxylate

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/1099-0690(200212)2002:24<4190::AID-EJOC4190>3.0.CO;2-Q

Reference yield:

tert-butyl 1-benzyl-3-methyl-6-oxoperhydropyridazine-3-carboxylate (528868-63-5) → tert-butyl 1-benzylamino-2-methyl-5-oxopyrrolidine-2-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / LiHMDS / tetrahydrofuran / -78 - 20 °C

2: 90 percent / hydrazine hydrate / Pd/C / methanol / 24 h / Heating

With hydrazine hydrate; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1002/1099-0690(200212)2002:24<4190::AID-EJOC4190>3.0.CO;2-Q

upstream raw materials:

methylmagnesium bromide

1-benzyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester