N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide

Base Information

Chemical Name:N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide
CAS No.:1491142-33-6
Molecular Formula:C₃₅H₃₃F₃N₆O₄
Molecular Weight:658.68
Hs Code.:

Synonyms:N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide

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Chemical Property of N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide

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Technology Process of N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide

There total 14 articles about N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 960299-67-6
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

: C₁₁H₅ClF₂N₂O

: 1491142-33-6
N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1016/j.ejmech.2013.08.019

Reference yield:

: 1221502-97-1
(2E)-1-(2,4-difluorophenyl)-3-(dimethylamino)prop-2-en-1-one

: 1491142-33-6
N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium ethanolate / ethanol / 70 °C

2: sulfuric acid; dihydrogen peroxide; ferrous(II) sulfate heptahydrate / 0 - 15 °C

3: sulfuric acid / 100 °C

4: thionyl chloride / 6 h / Reflux

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With ferrous(II) sulfate heptahydrate; thionyl chloride; sulfuric acid; dihydrogen peroxide; sodium ethanolate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.08.019

Reference yield:

: 1187176-51-7
4-(2,4-difluorophenyl)pyrimidine

: 1491142-33-6
N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(2,4-difluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; dihydrogen peroxide; ferrous(II) sulfate heptahydrate / 0 - 15 °C

2: sulfuric acid / 100 °C

3: thionyl chloride / 6 h / Reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With ferrous(II) sulfate heptahydrate; thionyl chloride; sulfuric acid; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2013.08.019