7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]

Base Information

Chemical Name:7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]
CAS No.:1038923-79-3
Molecular Formula:C₃₅H₄₃N₅O₅S
Molecular Weight:645.823
Hs Code.:

7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]

Synonyms:7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]

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Chemical Property of 7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]

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Technology Process of 7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]

There total 2 articles about 7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 52407-92-8
3-methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride

: 902148-42-9
13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

: 1038923-79-3
7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 902148-54-3
13-cyclohexyl-10-[[[(dimethylamino)sulfonyl]amino]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid methyl ester

: 1038923-79-3
7H-indolo[2,1-a][2]benzazepine-10-carboxamide,13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 0.25 h / 80 °C / Microwave irradiation

1.2: 20 °C

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With water; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;